What factors can affect drug metabolism in an elderly client and why?

Decreased liver size causes a reduction in the levels of drug-metabolizing enzymes, which affects drug metabolism. Elderly people experience atrophy in different organs, which affects the functionality of the same.

Additionally, loss of intestinal mucosal surface coupled with reduced gastric acidity affects the absorption of drugs in the elderly. After ingestion, drugs have to pass the mucosal intestinal wall, and the surface area of this wall determines the absorption rate. Large surface area means increased absorption.

On the other side, a small surface area implies a reduced absorption rate. Similarly, reduced blood flow due to age affects the distribution of drugs.
Finally, renal excretion is reduced as the size of kidneys decreases with age.

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Academic.Tips. (2022, November 23). What factors can affect drug metabolism in an elderly client and why? https://academic.tips/question/what-factors-can-affect-drug-metabolism-in-an-elderly-client-and-why/

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Academic.Tips. 2022. "What factors can affect drug metabolism in an elderly client and why?" November 23, 2022. https://academic.tips/question/what-factors-can-affect-drug-metabolism-in-an-elderly-client-and-why/.

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Academic.Tips. "What factors can affect drug metabolism in an elderly client and why?" November 23, 2022. https://academic.tips/question/what-factors-can-affect-drug-metabolism-in-an-elderly-client-and-why/.

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