Using the following mRNA sequence, provide a definition and an example of each of the following mutations: silent, nonsense, missense, and frameshift mutation. AUG GUG CCA UUC AAU AUG UGG

A silent mutation is a codon mutation, which does not result in a change of amino acid after the alteration. For example, GUG encodes an amino acid called Valine, and the following change would be an instance of silent mutation. Since both GUG and GUA code Valine, the change of the third nucleotide from G to A is a silent mutation.

AUG GUA CCA UUC AAU AUG UGG

A nonsense mutation is a mutation that leads to a premature stop of protein synthesis or translation. It usually involves other codons changing to stop codons, such as UGA, UAA, and UAG. For example, UGG change to UGA would be a nonsense mutation, as shown below.

AUG GUG CCA UUC AAU AUG UGA

A missense mutation results in a codon change, which leads to a change in amino acids. For example, CCA change to UCA would result in proline being replaced by serine, as shown below.

AUG GUG UCA UUC AAU AUG UGG

A frameshift mutation is a change of codon reading frame through insertion or deletion of one nucleotide or nucleotides. For example, if A is inserted after AUG, then the rest of the molecule will be incorrectly read to change in the frame, as shown below.

AUG AGU GCC AUU CAA UAU GUG G

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Academic.Tips. (2022) 'Using the following mRNA sequence, provide a definition and an example of each of the following mutations: silent, nonsense, missense, and frameshift mutation. AUG GUG CCA UUC AAU AUG UGG'. 7 October.

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Academic.Tips. (2022, October 7). Using the following mRNA sequence, provide a definition and an example of each of the following mutations: silent, nonsense, missense, and frameshift mutation. AUG GUG CCA UUC AAU AUG UGG. https://academic.tips/question/using-the-following-mrna-sequence-provide-a-definition-and-an-example-of-each-of-the-following-mutations-silent-nonsense-missense-and-frameshift-mutation-aug-gug-cca-uuc-aau-aug-ugg/

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Academic.Tips. 2022. "Using the following mRNA sequence, provide a definition and an example of each of the following mutations: silent, nonsense, missense, and frameshift mutation. AUG GUG CCA UUC AAU AUG UGG." October 7, 2022. https://academic.tips/question/using-the-following-mrna-sequence-provide-a-definition-and-an-example-of-each-of-the-following-mutations-silent-nonsense-missense-and-frameshift-mutation-aug-gug-cca-uuc-aau-aug-ugg/.

1. Academic.Tips. "Using the following mRNA sequence, provide a definition and an example of each of the following mutations: silent, nonsense, missense, and frameshift mutation. AUG GUG CCA UUC AAU AUG UGG." October 7, 2022. https://academic.tips/question/using-the-following-mrna-sequence-provide-a-definition-and-an-example-of-each-of-the-following-mutations-silent-nonsense-missense-and-frameshift-mutation-aug-gug-cca-uuc-aau-aug-ugg/.


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Academic.Tips. "Using the following mRNA sequence, provide a definition and an example of each of the following mutations: silent, nonsense, missense, and frameshift mutation. AUG GUG CCA UUC AAU AUG UGG." October 7, 2022. https://academic.tips/question/using-the-following-mrna-sequence-provide-a-definition-and-an-example-of-each-of-the-following-mutations-silent-nonsense-missense-and-frameshift-mutation-aug-gug-cca-uuc-aau-aug-ugg/.

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"Using the following mRNA sequence, provide a definition and an example of each of the following mutations: silent, nonsense, missense, and frameshift mutation. AUG GUG CCA UUC AAU AUG UGG." Academic.Tips, 7 Oct. 2022, academic.tips/question/using-the-following-mrna-sequence-provide-a-definition-and-an-example-of-each-of-the-following-mutations-silent-nonsense-missense-and-frameshift-mutation-aug-gug-cca-uuc-aau-aug-ugg/.

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