Non-Steroidal Anti-Inflammatory Drugs Analgesics

What effect does heat have on nociceptors so that it makes a good nonpharmacologic treatment for pain?

Heat and cold treatment are both hypothesized to have an effect on the release of endogenous opioids. What are these chemicals, and why are they hypothesized to be beneficial in the body? Using knowledge of physiology, how do NSAID analgesics function in the management of pain? Discuss patient education topics you would discuss with the patient in the given situation.