How does KP46 synergize with other chemotherapeutic drugs like cisplatin to kill cancer cells?

KP46 is found to synergize successfully with such osteosarcoma agents as cisplatin and obatoclax, whereas it failed to synergize with methotrexate, doxorubicin, and venetoclax. As for cisplatin, Kubista et al. maintain that the reasons for such interaction are unknown, but they hypothesize that it may be explained by repair mechanisms or programmed cell death regulatory signals. As for obatoclax, it is stated that this agent can inhibit the process of autophagy which KP46, in its turn, induces and thus showcase more positive results than the two agents have separately.

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Academic.Tips. (2022, October 8). How does KP46 synergize with other chemotherapeutic drugs like cisplatin to kill cancer cells? https://academic.tips/question/how-does-kp46-synergize-with-other-chemotherapeutic-drugs-like-cisplatin-to-kill-cancer-cells/

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Academic.Tips. 2022. "How does KP46 synergize with other chemotherapeutic drugs like cisplatin to kill cancer cells?" October 8, 2022. https://academic.tips/question/how-does-kp46-synergize-with-other-chemotherapeutic-drugs-like-cisplatin-to-kill-cancer-cells/.

1. Academic.Tips. "How does KP46 synergize with other chemotherapeutic drugs like cisplatin to kill cancer cells?" October 8, 2022. https://academic.tips/question/how-does-kp46-synergize-with-other-chemotherapeutic-drugs-like-cisplatin-to-kill-cancer-cells/.


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Academic.Tips. "How does KP46 synergize with other chemotherapeutic drugs like cisplatin to kill cancer cells?" October 8, 2022. https://academic.tips/question/how-does-kp46-synergize-with-other-chemotherapeutic-drugs-like-cisplatin-to-kill-cancer-cells/.

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"How does KP46 synergize with other chemotherapeutic drugs like cisplatin to kill cancer cells?" Academic.Tips, 8 Oct. 2022, academic.tips/question/how-does-kp46-synergize-with-other-chemotherapeutic-drugs-like-cisplatin-to-kill-cancer-cells/.

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